方法 比较彻底，除 Ctrl Alt Del 之外全被屏蔽。
在程序中设置如下全局变量和全局函数：
// 钩子句柄
HHOOK OldHook;

long CALLBACK KeyProc(int code, WPARAM wParam, LPARAM lParam)
{
KBDLLHOOKSTRUCT *pkbhs;
if (code < 0)
{
return CallNextHookEx(OldHook, code, wParam, lParam);
}
pkbhs = (KBDLLHOOKSTRUCT*) lParam;
if (pkbhs->vkCode == 91 || pkbhs->vkCode == VK_RWIN)//封锁 win 键
{
return 1;
}
if (pkbhs->vkCode == VK_ESCAPE && GetAsyncKeyState(VK_CONTROL) < 0)
{
return 1; //封锁 CTRL ESC
}
if (pkbhs->vkCode == VK_TAB && pkbhs->flags&LLKHF_ALTDOWN)
{
return 1; //封锁 ALT TAB
}
if (pkbhs->vkCode == 115 && pkbhs->flags & LLKHF_ALTDOWN)
{
return 1; //封锁 ALT F4
}
if (pkbhs->vkCode == VK_ESCAPE && pkbhs->flags & LLKHF_ALTDOWN)
{
return 1; //封锁 ALT ESC
}
if (pkbhs->vkCode == VK_SPACE && GetAsyncKeyState(VK_CONTROL) < 0)
{
return 1; //封锁 CTRL ' '
}
return CallNextHookEx(OldHook, code, wParam, lParam);
}
然后就可以屏蔽和启用系统热键了
// 屏蔽热键
OldHook = SetWindowsHookEx(WH_KEYBOARD_LL, (HOOKPROC)KeyProc, HInstance, 0);
// 启用热键
UnhookWindowsHookEx(OldHook);

这个方法 应该是现在最常用的了